Full article Telomere length has been accepted widely as a biomarker of aging.
Recently, a novel candidate biomarker has been suggested to predict an individual’s chronological age with high accuracy: The epigenetic clock is based on the weighted DNA methylation (DNAm) fraction of a number [...] Read more.
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Telomere dynamics have been found to be better predictors of survival and mortality than chronological age.
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There is an Article Processing Charge (APC) for publication in this open access journal. Submitted papers should be well formatted and use good English.Our growing understanding of the mechanisms of telomerase up-regulation during cancer development might help in tumour prognosis and in the development of new anti-cancer treatments and therapies.In addition, many telomere-independent functions for the telomerase reverse transcriptase protein TERT have been discovered, which add to the complexity of telomerase and the multitude of its functions.A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page.is an international peer-reviewed open access semimonthly journal published by MDPI.Telomerase activity is under tight physiological regulation in human tissues, where the enzyme is active in only a few adult tissues, such as endothelial cells and lymphocytes, but can be up-regulated in many types of adult stem cells.Telomere shortening has been associated with cellular senescence and the aging process, as well as major diseases, such as atherosclerosis, obesity, and cardiovascular disease.Telomere length has been accepted widely as a biomarker of aging.Recently, a novel candidate biomarker has been suggested to predict an individual’s chronological age with high accuracy: The epigenetic clock is based on the weighted DNA methylation (DNAm) fraction of a number of cytosine-phosphate-guanine sites (Cp Gs) selected by penalized regression analysis.You can also change the view style at any point from the main header when using the pages with your mobile device.Ageing Biology Centre and Institute for Cell and Molecular Biosciences, Campus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne, NE4 5PL, UK Interests: telomerase in ageing and cancer; TERT in mitochondria and brain; oxidative stress; mitochondria; senescence and ageing Dear Colleagues, Telomeres and telomerase receive ever-increasing interest from the scientific community.